Nowadays, bone marrow(BM) biopsy is performed world widely, not only for correct
diagnosis of hematologic disorders, but also for the evaluation of their therapeutic
effects, prognosis, and detection of myelofibrosis and secondary marrow involvement. Six
hundred forty-two slides of BM biopsy were reviewed. The classification of the diseases
was acute leukemia(19.5%), IDA(8.6%), aplastic anemia(6.7%), myeloproliferative disease
(5.6%) etc., in order. Marked cellularity discrepancy between aspiration and biopsy was
noted in 55 of 505(10.9%).
In 75 cases of myelofibrosis(MF), CML was the most(17 3%) and MF of unknown
etiology was 9 casts(12.0%). ALL showed higher frequency and more severe grading in
MF than AML. In 54 cases of solid tumor, BM metastasis was noted in 25(46.3%)
(metastatic adenocarcinoma : 55%, small cell carcinoma of the lung : 10%), and MF was
combined in 6 (24%). In 9 cases of NHL, 6 showed diffuse infiltration and 2 showed
nodular in biopsy. MF was combined in 3. The 10 cases of follow up BM biopsy during
therapy were reviewed, and 5 cases of AML showed decreased cellularity and increased
fat cells of marrow after 1 month or more. Five cases of CML showed decreased or
increased MF and cellularity according to the disease progression.
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